BDBM11946 (3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-(trifluoromethyl)-2H,4H,5H,6H,7H-pyrazolo[4,3-c]pyridin-5-yl]butan-1-one::pyrazolopiperidine 48

SMILES Cn1nc2CCN(Cc2c1C(F)(F)F)C(=O)C[C@H](N)Cc1cc(F)ccc1F

InChI Key InChIKey=DXPLWSRNTJOVFI-GFCCVEGCSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 11946   

TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM11946((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Affinity DataIC50:  150nMpH: 7.5 T: 2°CAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM11946((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Affinity DataIC50: >1.00E+5nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM11946((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Affinity DataIC50: >1.00E+5nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 2(Homo sapiens (Human))
Merck Research Laboratories

LigandPNGBDBM11946((3R)-3-amino-4-(2,5-difluorophenyl)-1-[2-methyl-3-...)
Affinity DataIC50:  5.10E+4nMAssay Description:The enzyme activity resulted in the formation of the fluorescent product amidomethylcoumarin (AMC), which was monitored by excitation at 360 nm and m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed