BDBM12079 6-Chloro-4-cyclohexyloxy-3-isopropylquinol-2-one::6-chloro-4-(cyclohexyloxy)-3-(propan-2-yl)-1,2-dihydroquinolin-2-one::quinolone-based inhibitor 2b

SMILES CC(C)c1c(OC2CCCCC2)c2cc(Cl)ccc2[nH]c1=O

InChI Key InChIKey=OQCFORGSZJSAEL-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 12079   

TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
University of Oxford

LigandPNGBDBM12079(6-Chloro-4-cyclohexyloxy-3-isopropylquinol-2-one |...)
Affinity DataIC50:  630nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1127,L687I]/[588-1147,L687I](Human immunodeficiency virus type 1)
University of Oxford

LigandPNGBDBM12079(6-Chloro-4-cyclohexyloxy-3-isopropylquinol-2-one |...)
Affinity DataIC50:  1.96E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1127,Y768C]/[588-1147,Y768C](Human immunodeficiency virus type 1)
University of Oxford

LigandPNGBDBM12079(6-Chloro-4-cyclohexyloxy-3-isopropylquinol-2-one |...)
Affinity DataIC50:  2.50E+3nMpH: 7.8 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair