BDBM12318 6-(1H-indol-5-yloxy)-5-[(1E)-(methoxyimino)methyl]pyrimidin-4-amine::oxime analog 7

SMILES CO\N=C\c1c(N)ncnc1Oc1ccc2[nH]ccc2c1

InChI Key InChIKey=RBOIGEMDWWVEJC-FBCYGCLPSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 12318   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM12318(6-(1H-indol-5-yloxy)-5-[(1E)-(methoxyimino)methyl]...)
Affinity DataIC50:  146nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM12318(6-(1H-indol-5-yloxy)-5-[(1E)-(methoxyimino)methyl]...)
Affinity DataIC50:  276nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed