BDBM12327 6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-[(1E)-[(prop-2-en-1-yloxy)imino]methyl]pyrimidin-4-amine::oxime analog 16
SMILES Cc1cc2c(F)c(Oc3ncnc(N)c3\C=N\OCC=C)ccc2[nH]1
InChI Key InChIKey=FXBNWAKVMJGXJE-GZIVZEMBSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 12327
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Tsing Hua University
Curated by ChEMBL
National Tsing Hua University
Curated by ChEMBL
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of RET kinaseMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical
Johnson & Johnson Pharmaceutical
Affinity DataIC50: 52nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair