BDBM12337 6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-[(1E)-[(3-methoxypropoxy)imino]methyl]pyrimidin-4-amine::oxime analog 26

SMILES COCCCO\N=C\c1c(N)ncnc1Oc1ccc2[nH]c(C)cc2c1F

InChI Key InChIKey=YSMSWYULVKNYGX-NUGSKGIGSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 12337   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
National Tsing Hua University

Curated by ChEMBL
LigandPNGBDBM12337(6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-[(1E)-[...)
Affinity DataIC50:  1.00E+3nMAssay Description:Inhibition of RET kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Rattus norvegicus (rat))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM12337(6-[(4-fluoro-2-methyl-1H-indol-5-yl)oxy]-5-[(1E)-[...)
Affinity DataIC50:  62nMpH: 8.0 T: 2°CAssay Description:The enzyme was assayed with a biotinylated peptide substrate and test compounds in the presence of 5 uM ATP/[gamma-33P]ATP in a streptavidin coated F...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed