BDBM123756 1-methyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine (15)

SMILES Cn1nc(-c2ccc3ccccc3c2)c2c(N)ncnc12

InChI Key InChIKey=UOKGZPYGRJDACN-UHFFFAOYSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 123756   

TargetPhospholipase D1(Homo sapiens (Human))
University of Massachusetts Boston

LigandPNGBDBM123756(1-methyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  250nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase D(Streptomyces chromofuscus)
Roxbury Community College

LigandPNGBDBM123756(1-methyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  12nMpH: 8.0Assay Description:A NaOH stock solution (50 mM) was standardized with KHP then diluted in Millipore water (10-fold serial dilutions) then used to hold the pH constant ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase D(Streptomyces sp. PMF)
University of Massachusetts Boston

LigandPNGBDBM123756(1-methyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  650nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhospholipase D2(Homo sapiens (Human))
University of Massachusetts Boston

LigandPNGBDBM123756(1-methyl-3-(naphthalen-2-yl)-1H-pyrazolo[3,4-d]pyr...)
Affinity DataIC50:  1.20E+3nMT: 2°CAssay Description:PLD enzymes (50 nM) were reconstituted with phospholipid vesicle substrates. All assays were performed at 37 C with agitation for 30 min. Reactions...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed