BDBM125040 Roche-Dataset for PDE10A, Compound 21::US8772510, 59

SMILES Cn1ncc(C(=O)N2CCC2)c1C(=O)NCCc1nc(nn1-c1cccnc1)-c1ccccc1

InChI Key InChIKey=JTBLKZLWPQJLMV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 125040   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM125040(Roche-Dataset for PDE10A, Compound 21 | US8772510,...)
Affinity DataIC50:  0.510nMAssay Description:Human PDE10A IC50 values were determined by using purified enzyme (Biomol cat. # SE-534) in a scintillation proximity assay (SPA) in 96 well plates (...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A(Homo sapiens (Human))
F. Hoffmann-La Roche

LigandPNGBDBM125040(Roche-Dataset for PDE10A, Compound 21 | US8772510,...)
Affinity DataIC50:  0.530nMAssay Description:PDE10 activity of the compounds of the present invention was determined using a Scintillation Proximity Assay (SPA)-based method similar to the one p...More data for this Ligand-Target Pair
In DepthDetails US Patent