BDBM13215 2-Aminothiazole 1::2-amino-4-methyl-N-(2,4,6-trimethylphenyl)-1,3-thiazole-5-carboxamide::CHEMBL307976

SMILES Cc1nc(N)sc1C(=O)Nc1c(C)cc(C)cc1C

InChI Key InChIKey=NJHVQEJXKUFUMU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13215   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13215(2-Aminothiazole 1 | 2-amino-4-methyl-N-(2,4,6-trim...)
Affinity DataIC50:  5.00E+3nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13215(2-Aminothiazole 1 | 2-amino-4-methyl-N-(2,4,6-trim...)
Affinity DataIC50:  6.60E+3nMAssay Description:Inhibition of mouse p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13215(2-Aminothiazole 1 | 2-amino-4-methyl-N-(2,4,6-trim...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13215(2-Aminothiazole 1 | 2-amino-4-methyl-N-(2,4,6-trim...)
Affinity DataIC50:  3.20E+3nMAssay Description:In vitro inhibition of phosphorylation ofan exogenous substrate by human p56 Lck tyrosine kinase expressed as a Histagged protein in insect cells usi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed