BDBM13219 2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,6-dimethylphenyl)-1,3-thiazole-5-carboxamide::BMS-354825 tert-Butoxycarbamate Analog 5c::CHEMBL129454::tert-butyl N-{5-[(2,6-dimethylphenyl)carbamoyl]-4-methyl-1,3-thiazol-2-yl}carbamate

SMILES Cc1nc(NC(=O)OC(C)(C)C)sc1C(=O)Nc1c(C)cccc1C

InChI Key InChIKey=YKIPORXJATYHIG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 13219   

TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13219(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Affinity DataIC50:  4.40E+3nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13219(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of mouse p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM13219(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of human p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase LCK(Mus musculus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM13219(2-[[(tert-Butyloxy)carbonyl]-amino]-4-methyl-N-(2,...)
Affinity DataIC50:  7.50E+3nMpH: 7.0 T: 2°CAssay Description:IC50 is the inhibitor concentration, which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-33P] lab...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed