BDBM13314 5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-{2-[(4-cyanophenyl)-(3-methyl-3H-imidazol-4-ylmethyl)amino]ethyl}-amide::N-benzyl-N-{2-[(4-cyanophenyl)[(1-methyl-1H-imidazol-5-yl)methyl]amino]ethyl}-5-(dimethylamino)naphthalene-1-sulfonamide::Sulfonamide 12i

SMILES CN(C)c1cccc2c(cccc12)S(=O)(=O)N(CCN(Cc1cncn1C)c1ccc(cc1)C#N)Cc1ccccc1

InChI Key InChIKey=PLJBZEPECJYWNJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 13314   

TargetATP-dependent RNA helicase RhlE(Plasmodium falciparum (malaria parasite P. falcipa...)
Yale University

LigandPNGBDBM13314(5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-...)
Affinity DataIC50:  55nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13314(5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-...)
Affinity DataIC50:  180nMpH: 7.5 T: 2°CAssay Description:Assays for PFT activity were performed with a PFT-specific scintillation assay (SPA) kit (Amersham Biosciences, Piscataway, NJ). IC50 values were cal...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13314(5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-...)
Affinity DataIC50:  160nMAssay Description:Inhibition of human farnesyltransferase assessed as incorporation of [3H]FPP into H-Ras-CVLSMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13314(5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of H-Ras farnesylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13314(5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Rap1A-mediated geranylgeranylation expressed in mouse NIH3T3 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13314(5-Dimethylaminonaphthalene-1-sulfonic Acid Benzyl-...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of human geranylgeranyltransferase-1 assessed as incorporation of [3H]GGPP into H-Ras-CVLLMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed