BDBM134348 US8846658, 60

SMILES CC1(COCC(N)=N1)c1cc(NC(=O)c2ccc(Br)cn2)ccc1F

InChI Key InChIKey=AWWAZUFXKKZKCD-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 134348   

TargetBeta-secretase 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134348(US8846658, 60)
Affinity DataIC50:  58nMpH: 4.5 T: 2°CAssay Description:Recombinant BACE-1 (extracellular domain, expressed in baculovirus and purified using standard methods) at 0.1 to 10 nM concentrations is incubated w...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM134348(US8846658, 60)
Affinity DataIC50:  3nMAssay Description:Inhibition of wild type human APP751 expressed in CHO cells incubated for 24 hrs by immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM134348(US8846658, 60)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of human cathepsin D using Mca-GKPILFFRLK(DNP)D-R-NH2 as a substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM134348(US8846658, 60)
Affinity DataIC50:  58nMAssay Description:Inhibition of human recombinant BACE1 catalytic domain using FRET substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed