BDBM136761 US10231967, Example 20u::US8865911, 20u::US9000182, 10::US9918985, Example 20u
SMILES CO[C@H]1CC[C@@]2(Cc3ccc(OCCC(F)(F)F)cc3C22N=C(C)C(N)=N2)CC1
InChI Key InChIKey=JJEORDNWHQBLEW-PRESFXJZSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 136761
Affinity DataIC50: 22nMpH: 9.2Assay Description:The beta-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human beta-Secretase (AA 1-AA 460) was clo...More data for this Ligand-Target Pair
Affinity DataIC50: 530nMpH: 2.5Assay Description:The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human (3-Secretase (AA 1-AA 460) was clone...More data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMpH: 2.5Assay Description:TR-FRET Assay: The beta -secretase enzyme used in the TR-FRET is prepared as follows:The cDNA for the soluble part of the human (3-Secretase (AA 1-AA...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:The enzyme (truncated form) was diluted to 6 μg/mL (stock 1.3 mg/mL) and the substrate (Europium)CEVNLDAEFK(Qsy7) to 200 nM (stock 120 μM) ...More data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMAssay Description:The β-secretase enzyme used in the TR-FRET is prepared as follows: The cDNA for the soluble part of the human β-Secretase (AA 1-AA 460) was...More data for this Ligand-Target Pair
Affinity DataIC50: 0.630nMAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at −140° C. at a ...More data for this Ligand-Target Pair
Affinity DataIC50: 56nMT: 2°CAssay Description:SH-SY5Y cells were cultured in DMEM/F-12 with Glutamax, 10% FCS and 1% non-essential amino acids and cryopreserved and stored at -140 C. at a concent...More data for this Ligand-Target Pair