BDBM138224 US8871738, 62::US8871738, 7

SMILES COc1cc(F)c(cc1-c1ccc(cc1[C@@H]1CC[C@H]2[C@H](OC(=O)N12)c1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(F)(F)F)-c1ccc(cc1C)C(O)=O

InChI Key InChIKey=CZRMENLRCXEIFA-GSBZAIBZSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 138224   

TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM138224(US8871738, 62 | US8871738, 7)
Affinity DataIC50:  53.7nMpH: 7.4 T: 2°CAssay Description:First, low density lipoprotein (LDL) (Meridian) was biotinylated by incubating LDL with biotin for 1 hour on ice, after which it was dialyzed to remo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCholesteryl ester transfer protein(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM138224(US8871738, 62 | US8871738, 7)
Affinity DataIC50:  172nMpH: 7.4 T: 2°CAssay Description:First, low density lipoprotein (LDL) (Meridian) was biotinylated by incubating LDL with biotin for 1 hour on ice, after which it was dialyzed to remo...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSolute carrier organic anion transporter family member 1B1(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM138224(US8871738, 62 | US8871738, 7)
Affinity DataIC50: <1.00E+3nMAssay Description:Inhibition of OATP1B1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM138224(US8871738, 62 | US8871738, 7)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of Cav1.2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C8(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM138224(US8871738, 62 | US8871738, 7)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of CYP2C8 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Merck

Curated by ChEMBL
LigandPNGBDBM138224(US8871738, 62 | US8871738, 7)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of Nav1.5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed