BDBM138497 US8877775, 8::US9073869, 8
SMILES CS(=O)(=O)c1cc(ccc1C#N)-c1ccc(C[C@H](NC(=O)[C@H]2NC3CCC2CC3)C#N)cc1
InChI Key InChIKey=VEFUKSHSYMURRC-YRTXYGLRSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 138497
Affinity DataIC50: 70.2nMpH: 6.0 T: 2°CAssay Description:The following buffers were used: MES buffer: 25 mM MES, 50 mM NaCl, 5 mM DTT, adjusted to pH 6.0, containing 0.1% BSA; TAGZyme Buffer: 20 mM NaH2P04,...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMT: 2°CAssay Description:To activate the proenzyme, 5 ul procathepsin K were mixed with 1 ul activation buffer, and incubated at room temperature for 30 min.5 uL test compoun...More data for this Ligand-Target Pair
Affinity DataIC50: 70.2nMT: 2°CAssay Description:The recombinant human DPPI was diluted in TAGZyme buffer to 1 U/ml (38.1 ug/ml, respectively), and then activated by mixing in a 1:2 ratio with a Cys...More data for this Ligand-Target Pair
Affinity DataIC50: 5.30E+3nMpH: 3.5 T: 2°CAssay Description:The following buffers were used: Activation buffer: 32.5 mM sodium acetate, adjusted to pH 3.5 with HCl; Assay buffer: 150 mM sodium acetate, 4mM EDT...More data for this Ligand-Target Pair