BDBM14052 N-(1H-indazol-5-yl)-2-methyl-4-(naphthalen-2-yl)-6-oxo-1,4,5,6-tetrahydropyridine-3-carboxamide::dihydropyridone indazole amide 12

SMILES CC1=C(C(CC(=O)N1)c1ccc2ccccc2c1)C(=O)Nc1ccc2[nH]ncc2c1

InChI Key InChIKey=ODLNBFNBEPOFNC-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 14052   

TargetRho-associated protein kinase 1(Homo sapiens (Human))
Glaxosmithkline

LigandPNGBDBM14052(N-(1H-indazol-5-yl)-2-methyl-4-(naphthalen-2-yl)-6...)
Affinity DataIC50:  9nMpH: 7.4 T: 2°CAssay Description:The assay of Rock-1 activity involved incubation with peptide substrate and ATP/[gamma-33P] ATP, the subsequent incorporation of 33P into the peptid...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG protein-coupled receptor kinase 5(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM14052(N-(1H-indazol-5-yl)-2-methyl-4-(naphthalen-2-yl)-6...)
Affinity DataIC50:  6.31E+4nMAssay Description:Inhibition of bovine GRK5 assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRhodopsin kinase GRK1(Bos taurus)
Universit£

Curated by ChEMBL
LigandPNGBDBM14052(N-(1H-indazol-5-yl)-2-methyl-4-(naphthalen-2-yl)-6...)
Affinity DataIC50:  7.94E+5nMAssay Description:Inhibition of bovine GRK1 (1 to 535 residues) assessed as decrease in phosphorylation of tubulin after 5 mins by SDS-PAGE analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed