BDBM14171 APC-7538::Thieno[2,3-b]pyridine-2-carboxamidine::[amino(thieno[2,3-b]pyridin-2-yl)methylidene]azanium

SMILES NC(=[NH2+])c1cc2cccnc2s1

InChI Key InChIKey=GZEJMYFXZMUAEC-UHFFFAOYSA-O

Data  6 KI

PDB links: 3 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14171   

TargetTryptase beta-2(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14171(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)
Affinity DataKi:  3.40E+4nM ΔG°:  -6.03kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14171(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)
Affinity DataKi:  6.30E+4nM ΔG°:  -5.67kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetSerine protease 1(Bos taurus (bovine))
Axys Pharmaceutical

LigandPNGBDBM14171(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)
Affinity DataKi:  8.00E+4nM ΔG°:  -5.53kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
TargetCoagulation factor X(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14171(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)
Affinity DataKi:  3.60E+5nM ΔG°:  -4.65kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14171(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)
Affinity DataKi:  1.60E+6nM ΔG°:  -3.77kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Axys Pharmaceutical

LigandPNGBDBM14171(APC-7538 | Thieno[2,3-b]pyridine-2-carboxamidine |...)
Affinity DataKi:  1.80E+6nM ΔG°:  -3.70kcal/molepH: 7.4 T: 2°CAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed