BDBM142019 US10435361, Example 16::US8927563, I::US9481648, 16::US9790174, Example 16

SMILES COCCOCCOCCNC(=O)c1cc(Nc2nccc(Oc3ccc(NC(=O)Nc4cc(cc(NS(C)(=O)=O)c4OC)C(C)(C)C)c4ccccc34)n2)cc(c1)C#C

InChI Key InChIKey=FWXVGKSWZJEPQI-UHFFFAOYSA-N

Data  17 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 142019   

TargetMitogen-activated protein kinase 14(Human)
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Affinity DataIC50: 224nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a higher concentration of the p38 MAPKα protein (2.5 uL of 200 ng/...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/30/2017
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
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Affinity DataIC50: 3.00E+3nMAssay Description:Compounds of the invention were tested for inhibition of the human ether a go-go (hERG) channel using IonWorks patch clamp electrophysiology at Essen...More data for this Ligand-Target Pair

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UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/30/2017
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TargetCytochrome P450 2C9(Human)
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Affinity DataIC50: 1.50E+4nMAssay Description:Summary of CYP2C9 inhibition studies for various Compound Examples using 30 min preincubation.More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/30/2017
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TargetCytochrome P450 2C9(Human)
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Affinity DataIC50: 1.50E+4nMAssay Description:Summary of CYP2C9 inhibition studies for various Compound Examples using 0 min preincubation.More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/30/2017
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TargetCytochrome P450 3A4(Human)
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LigandBDBM142019(US8927563, I | US9481648, 16 | US9790174, Example ...)Copy SMILESCopy InChI

Affinity DataIC50: 7.80E+3nMAssay Description:Summary of CYP3A4 inhibition studies for various Compound Examples using 30 min preincubation.More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/30/2017
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TargetCytochrome P450 3A4(Human)
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Affinity DataIC50: 1.50E+4nMAssay Description:Summary of CYP3A4 inhibition studies for various Compound Examples using 0 min preincubation.More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProtUniProtKB/TrEMBL
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/30/2017
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TargetGlycogen synthase kinase-3 alpha(Human)
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Affinity DataIC50: 411nMAssay Description:Method 2: This method follows the same steps as Method 1 above, but utilises a shorter period of mixing of the test compound (105 minutes instead of ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
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Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/30/2017
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TargetTyrosine-protein kinase SYK(Human)
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LigandBDBM142019(US8927563, I | US9481648, 16 | US9790174, Example ...)Copy SMILESCopy InChI

Affinity DataIC50: 591nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

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Date in BDB:
10/30/2017
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
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LigandBDBM142019(US8927563, I | US9481648, 16 | US9790174, Example ...)Copy SMILESCopy InChI

Affinity DataIC50: 24nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
10/30/2017
Entry Details
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TargetMitogen-activated protein kinase 14(Human)
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Affinity DataIC50: 224nMAssay Description:The following two assay variants can be used for determination of p38 MAPKα inhibition.Method 1The inhibitory activities of test compounds again...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/9/2019
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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LigandBDBM142019(US8927563, I | US9481648, 16 | US9790174, Example ...)Copy SMILESCopy InChI

Affinity DataIC50: 411nMAssay Description:Method 1: The inhibitory activities of the compound of the invention against the GSK 3alpha enzyme isoform (Invitrogen), are evaluated by determining...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/1/2015
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
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US Patent

LigandBDBM142019(US8927563, I | US9481648, 16 | US9790174, Example ...)Copy SMILESCopy InChI

Affinity DataIC50: 591nMAssay Description:The inhibitory activities of the compound of the invention against c-Src and Syk enzymes (Invitrogen) are evaluated in a similar fashion to that desc...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/1/2015
Entry Details
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TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent

LigandBDBM142019(US8927563, I | US9481648, 16 | US9790174, Example ...)Copy SMILESCopy InChI

Affinity DataIC50: 24nMAssay Description:The inhibitory activities of the compound of the invention against c-Src and Syk enzymes (Invitrogen) are evaluated in a similar fashion to that desc...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/1/2015
Entry Details
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TargetMitogen-activated protein kinase 12(Human)
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Affinity DataIC50: 224nMAssay Description:The inhibitory activities of compounds of the invention against p38MAPKγ (MAPK12: Invitrogen) are evaluated in a similar fashion to that describ...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
6/1/2015
Entry Details
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TargetGlycogen synthase kinase-3 alpha(Human)
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US Patent

LigandBDBM142019(US8927563, I | US9481648, 16 | US9790174, Example ...)Copy SMILESCopy InChI

Affinity DataIC50: 411nMAssay Description:The inhibitory activities of compounds of the invention against the GSK 3α enzyme isoform (Invitrogen), are evaluated by determining the level o...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/9/2019
Entry Details
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TargetTyrosine-protein kinase SYK(Human)
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US Patent

LigandBDBM142019(US8927563, I | US9481648, 16 | US9790174, Example ...)Copy SMILESCopy InChI

Affinity DataIC50: 591nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/9/2019
Entry Details
Copy BDB DOIUS Patent

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TargetProto-oncogene tyrosine-protein kinase Src(Human)
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US Patent

LigandBDBM142019(US8927563, I | US9481648, 16 | US9790174, Example ...)Copy SMILESCopy InChI

Affinity DataIC50: 24nMAssay Description:The inhibitory activities of compounds of the invention against c-Src and Syk enzymes (Invitrogen), are evaluated in a similar fashion to that descri...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoPC cidPC sidSimilars

In Depth
Date in BDB:
9/9/2019
Entry Details
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