BDBM14255 4-bromo-3-(carboxymethoxy)-5-[4-(dimethylamino)phenyl]thiophene-2-carboxylic acid::Monocyclic thiophene analog 24

SMILES CN(C)c1ccc(cc1)-c1sc(C(O)=O)c(OCC(O)=O)c1Br

InChI Key InChIKey=VSRQARFUSCWMHO-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 14255   

TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Miami

Curated by ChEMBL
LigandPNGBDBM14255(4-bromo-3-(carboxymethoxy)-5-[4-(dimethylamino)phe...)
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of PTPN1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14255(4-bromo-3-(carboxymethoxy)-5-[4-(dimethylamino)phe...)
Affinity DataKi:  1.00E+3nM ΔG°:  -8.18kcal/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14255(4-bromo-3-(carboxymethoxy)-5-[4-(dimethylamino)phe...)
Affinity DataKi:  1.60E+3nMAssay Description:Inhibition of PTPN2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14255(4-bromo-3-(carboxymethoxy)-5-[4-(dimethylamino)phe...)
Affinity DataKi:  9.00E+3nM ΔG°:  -6.88kcal/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
University Of Miami

Curated by ChEMBL
LigandPNGBDBM14255(4-bromo-3-(carboxymethoxy)-5-[4-(dimethylamino)phe...)
Affinity DataKi:  6.40E+4nMAssay Description:Inhibition of PTPRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase F(Homo sapiens (Human))
University Of Miami

Curated by ChEMBL
LigandPNGBDBM14255(4-bromo-3-(carboxymethoxy)-5-[4-(dimethylamino)phe...)
Affinity DataKi: >1.00E+6nMAssay Description:Inhibition of PTPRFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed