BDBM14258 4-bromo-3-(carboxymethoxy)-5-[4-(pyridine-3-amido)phenyl]thiophene-2-carboxylic acid::CHEMBL214378::Monocyclic thiophene analog 27

SMILES OC(=O)COc1c(Br)c(sc1C(O)=O)-c1ccc(NC(=O)c2cccnc2)cc1

InChI Key InChIKey=PTBNMQSAVVUNTG-UHFFFAOYSA-N

Data  6 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 14258   

TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14258(4-bromo-3-(carboxymethoxy)-5-[4-(pyridine-3-amido)...)
Affinity DataKi:  680nM ΔG°:  -8.41kcal/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Miami

Curated by ChEMBL
LigandPNGBDBM14258(4-bromo-3-(carboxymethoxy)-5-[4-(pyridine-3-amido)...)
Affinity DataKi:  680nMAssay Description:Inhibition of PTPN1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14258(4-bromo-3-(carboxymethoxy)-5-[4-(pyridine-3-amido)...)
Affinity DataKi:  820nM ΔG°:  -8.30kcal/moleT: 2°CAssay Description:The enzymatic assay was carried out at room temperature in 96-well plates. The initial rate of PTPase-catalyzed hydrolysis of p-nitrophenol phosphate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM14258(4-bromo-3-(carboxymethoxy)-5-[4-(pyridine-3-amido)...)
Affinity DataKi:  820nMAssay Description:Inhibition of PTPN2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase C(Homo sapiens (Human))
University Of Miami

Curated by ChEMBL
LigandPNGBDBM14258(4-bromo-3-(carboxymethoxy)-5-[4-(pyridine-3-amido)...)
Affinity DataKi:  5.50E+4nMAssay Description:Inhibition of PTPRCMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase F(Homo sapiens (Human))
University Of Miami

Curated by ChEMBL
LigandPNGBDBM14258(4-bromo-3-(carboxymethoxy)-5-[4-(pyridine-3-amido)...)
Affinity DataKi:  3.20E+5nMAssay Description:Inhibition of PTPRFMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
University Of Miami

Curated by ChEMBL
LigandPNGBDBM14258(4-bromo-3-(carboxymethoxy)-5-[4-(pyridine-3-amido)...)
Affinity DataIC50:  820nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase F(Homo sapiens (Human))
University Of Miami

Curated by ChEMBL
LigandPNGBDBM14258(4-bromo-3-(carboxymethoxy)-5-[4-(pyridine-3-amido)...)
Affinity DataIC50:  3.20E+5nMAssay Description:Inhibition of LAR (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed