BDBM14323 Fragment 20::quinazoline-2,4-diamine

SMILES Nc1nc(N)c2ccccc2n1

InChI Key InChIKey=XELRMPRLCPFTBH-UHFFFAOYSA-N

Data  2 KI  2 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 14323   

TargetDihydrofolate reductase(Rat)
TBA

Curated by ChEMBL
LigandPNGBDBM14323(quinazoline-2,4-diamine | Fragment 20)
Affinity DataIC50: 2.19E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
Targetm7GpppX diphosphatase(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM14323(quinazoline-2,4-diamine | Fragment 20)
Affinity DataIC50: 143nMAssay Description:Inhibition of human DcpS assessed as increase in SMN2 promoter activityMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetTryptase beta-2(Human)
Celera

LigandPNGBDBM14323(quinazoline-2,4-diamine | Fragment 20)
Affinity DataKi:  1.20E+6nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetSerine protease 1(Bovine)
Celera

LigandPNGBDBM14323(quinazoline-2,4-diamine | Fragment 20)
Affinity DataKi: >2.00E+6nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed