BDBM14323 Fragment 20::quinazoline-2,4-diamine

SMILES Nc1nc(N)c2ccccc2n1

InChI Key InChIKey=XELRMPRLCPFTBH-UHFFFAOYSA-N

Data  2 KI  2 IC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 14323   

TargetTryptase beta-2(Homo sapiens (Human))
Celera

LigandPNGBDBM14323(Fragment 20 | quinazoline-2,4-diamine)
Affinity DataKi:  1.20E+6nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Celera

LigandPNGBDBM14323(Fragment 20 | quinazoline-2,4-diamine)
Affinity DataKi: >2.00E+6nMAssay Description:Each enzyme was assayed with a set of different concentrations of each inhibitor. After addition of the appropriate substrate, the rate of hydrolysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM14323(Fragment 20 | quinazoline-2,4-diamine)
Affinity DataIC50:  2.19E+4nMAssay Description:Inhibitory activity against dihydrofolate reductase of rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Targetm7GpppX diphosphatase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM14323(Fragment 20 | quinazoline-2,4-diamine)
Affinity DataIC50:  143nMAssay Description:Concentration required for the inhibition of acetylcholinesteraseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed