BDBM14389 3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-fluoro-benzyloxy)-ethyl]-3H-purin-6-ylamine::3-{[3-(cyclopentyloxy)-4-methoxyphenyl]methyl}-8-{1-[(4-fluorophenyl)methoxy]ethyl}-3H-purin-6-amine::V11294 Analogue 8c

SMILES COc1ccc(Cn2cnc(N)c3nc(nc23)C(C)OCc2ccc(F)cc2)cc1OC1CCCC1

InChI Key InChIKey=AZEYTBCGGJIEGL-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14389   

TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14389(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-fluo...)
Affinity DataKi:  115nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14389(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-fluo...)
Affinity DataKi:  231nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14389(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-fluo...)
Affinity DataKi:  269nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14389(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-fluo...)
Affinity DataKi:  3.39E+3nM ΔG°:  -7.38kcal/molepH: 8.0 T: 2°CAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Purdue Pharma

LigandPNGBDBM14389(3-(3-Cyclopentyloxy-4-methoxy-benzyl)-8-[1-(4-fluo...)
Affinity DataKi:  4.30E+3nMAssay Description:PDE4 enzyme activity was monitored by measuring the hydrolysis of [3H]-cAMP to [3H]-AMP using SPA kit. [3H]-AMP was captured by the SPA beads, and qu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed