BDBM14476 3-bromo-8-chloro-7-fluoro-11-{4-[(1-oxidopyridin-4-yl)acetyl]piperazin-1-yl}-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine::4-[2-(4-{6-bromo-13-chloro-12-fluoro-4-azatricyclo[9.4.0.0^{3,8}]pentadeca-1(11),3,5,7,12,14-hexaen-2-yl}piperazin-1-yl)-2-oxoethyl]-1-oxidopyridin-1-ium::Trihalobenzocycloheptapyridine Tricyclic Compound 62

SMILES [O-][n+]1ccc(CC(=O)N2CCN(CC2)C2c3ccc(Cl)c(F)c3CCc3cc(Br)cnc23)cc1

InChI Key InChIKey=LOABUZOKOOMJLS-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 14476   

TargetProtein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha(Homo sapiens (Human))
Schering-Plough Research Institute

LigandPNGBDBM14476(3-bromo-8-chloro-7-fluoro-11-{4-[(1-oxidopyridin-4...)
Affinity DataIC50:  86nMpH: 7.5 T: 2°CAssay Description:FPT activity was determined by measuring transfer of [3H] farnesyl from [3H]farnesyl pyrophosphate to the substrate His6-Ha-Ras-CVLS. The incorporate...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed