BDBM14605 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyrazin-2-yl)urea::Chk1_76::N-pyrazinylurea Analog 7

SMILES COc1cc(N)c(Cl)cc1NC(=O)Nc1cnc(cn1)C#N

InChI Key InChIKey=DHDDCOYIWRLEJG-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 14605   

TargetSerine/threonine-protein kinase Chk1 [2-280](Homo sapiens (Human))
D3R/Abbott

LigandPNGBDBM14605(1-(4-amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyr...)
Affinity DataKi:  3.93nMAssay Description:33P-Radiometric_Method1More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14605(1-(4-amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyr...)
Affinity DataKi:  4nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14605(1-(4-amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyr...)
Affinity DataIC50:  4nMAssay Description:Abbott Kinase Enzymatics_CHK1/289 CDC25c - IC50(uM) (IC50)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14605(1-(4-amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyr...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM14605(1-(4-amino-5-chloro-2-methoxyphenyl)-3-(5-cyanopyr...)
Affinity DataIC50:  5nMAssay Description:ChemBL affinity - Published Abbott papersMore data for this Ligand-Target Pair
In DepthDetails PubMed