BDBM147644 US10766894, Compound TABLE 1.6::US11203595, TABLE 1.6::US8962608, 25-24::US8962608, 25-5

SMILES NC(=O)c1cn(nc1Nc1ccc(cc1)C(F)(F)F)[C@H]1CC[C@@H](O)C[C@@H]1C#N

InChI Key InChIKey=LHCPZEOULPJAHA-YVLXSGLVSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 147644   

TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)
Affinity DataIC50:  1nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)
Affinity DataIC50:  1nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)
Affinity DataIC50:  10nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)
Affinity DataIC50:  8nMAssay Description:The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and Tyk2 was measured using a recombinant purified GST-tagged catalytic domain ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)
Affinity DataIC50:  4nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [888-1187](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)
Affinity DataIC50:  110nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)
Affinity DataIC50:  1.00E+4nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)
Affinity DataIC50:  110nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK1 [866-1154](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)
Affinity DataIC50:  4nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2 [808-1132](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)
Affinity DataIC50:  150nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK3 [811-1124](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)
Affinity DataIC50:  1.00E+4nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM147644(US10766894, Compound TABLE 1.6 | US11203595, TABLE...)
Affinity DataIC50:  150nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 9 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
In DepthDetails US Patent