BDBM149682 US8975267, Ref. compound 3

SMILES Cn1c(c(C(N)=O)c2CCc3cnc(N)nc3-c12)-c1ccccc1

InChI Key InChIKey=KVWLHWMGSYRLAU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 149682   

TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM149682(US8975267, Ref. compound 3)
Affinity DataIC50: >5.00E+3nMpH: 3.0Assay Description:Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM149682(US8975267, Ref. compound 3)
Affinity DataIC50: >1.00E+4nMpH: 7.5Assay Description:The buffer for PIM-2 assay was composed of HEPES 50 mM, at pH 7.5, with 1 mM MgCl2, 1 mM DTT, 3 microM Na3VO4, and 0.2 mg/mL BSAFull-length human PIM...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM149682(US8975267, Ref. compound 3)
Affinity DataIC50: >5.00E+3nMpH: 3.0Assay Description:Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with 33P-gamma-...More data for this Ligand-Target Pair
In DepthDetails US Patent