BDBM150999 US8987257, 12
SMILES CC(O)c1cc(ccn1)-c1nc2c(nc(nc2[nH]1)N1CCOCC1)N1CCOC[C@@H]1C
InChI Key
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 150999
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Novartis
US Patent
Novartis
US Patent
Affinity DataIC50: 2.87E+3nMpH: 7.5 T: 2°CAssay Description:PI3K KinaseGlo assay: 50 mL of compound dilutions were dispensed onto black 384-well low volume Non Binding Styrene (NBS) plates (Costar Cat. No. NBS...More data for this Ligand-Target Pair
Affinity DataIC50: 2.02E+3nMpH: 7.5 T: 2°CAssay Description:IC50s for mTOR interacting compounds were assessed using the FRAP1/mTOR TR-FRET tracer assay (Invitrogen by Life Technologies). FRAP1/mTOR (PV4753) a...More data for this Ligand-Target Pair