BDBM15248 7-chloro-3-oxo-11,17-dioxa-2,4,20,22-tetraazatricyclo[16.3.1.0^{5,10}]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrile::CHEMBL220002::macrocyclic inhibitor 5b

SMILES Clc1ccc2OCCCCCOc3nc(NC(=O)Nc2c1)cnc3C#N

InChI Key InChIKey=OIJUFQYEGFLDAZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 15248   

TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15248(7-chloro-3-oxo-11,17-dioxa-2,4,20,22-tetraazatricy...)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:Chk1 kinase activity was assayed in reaction buffer containing substrate, enzyme, and inhibitor in the presence of 5uM ATP/[gamma-33P] ATP. 33P incor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15248(7-chloro-3-oxo-11,17-dioxa-2,4,20,22-tetraazatricy...)
Affinity DataIC50:  7nMAssay Description:Inhibition of Chk1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Abbott Laboratories

LigandPNGBDBM15248(7-chloro-3-oxo-11,17-dioxa-2,4,20,22-tetraazatricy...)
Affinity DataIC50:  11nMAssay Description:Inhibition of Chk1 enzyme by radiometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed