BDBM152697 (S)-5-Acetimidamido-2-aminopentanoic acid (4, L-NIO)::hDDAH inhibitor, 1e

SMILES CC(=N)NCCC[C@H](N)C(O)=O

InChI Key InChIKey=UYZFAUAYFLEHRC-LURJTMIESA-N

Data  2 KI  1 IC50

PDB links: 2 PDB IDs match this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 152697   

TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

LigandPNGBDBM152697((S)-5-Acetimidamido-2-aminopentanoic acid (4, L-NI...)
Affinity DataKi:  3.65E+3nM IC50:  8.10E+3nMpH: 7.4Assay Description:The assay mixture contained L-arginine (10 μM), NADPH (100 μM), oxyhemoglobin (0.125 mg/mL), tetrahydrobiopterin (10 μM), and differen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetN(G),N(G)-dimethylarginine dimethylaminohydrolase 1(Homo sapiens (Human))
Christian-Albrechts-University

LigandPNGBDBM152697((S)-5-Acetimidamido-2-aminopentanoic acid (4, L-NI...)
Affinity DataKi:  1.16E+6nM ΔG°:  -4.17kcal/molepH: 7.4 T: 2°CAssay Description:A colorimetric assay was carried out in 150 μL 50 mM potassium phosphate buffer pH 7.4 containing 4 μg of recombinant hDDAH-1 and varying c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed