BDBM152721 N-(3-{2-[3-(thiophene-2-imidamido)phenoxy]ethoxy}phenyl)thiophene-2-carboximidamide (26)::US9242957, 5

SMILES N=C(Nc1cccc(OCCOc2cccc(NC(=N)c3cccs3)c2)c1)c1cccs1

InChI Key InChIKey=FJVFGYSUSVNZDG-UHFFFAOYSA-N

Data  3 KI  1 Kd

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 152721   

TargetNitric oxide synthase, brain(Rattus norvegicus (rat))
Northwestern University

US Patent
LigandPNGBDBM152721(N-(3-{2-[3-(thiophene-2-imidamido)phenoxy]ethoxy}p...)
Affinity DataKi:  130nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNitric oxide synthase, endothelial(Bos taurus (bovine))
Northwestern University

US Patent
LigandPNGBDBM152721(N-(3-{2-[3-(thiophene-2-imidamido)phenoxy]ethoxy}p...)
Affinity DataKi:  1.37E+4nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetNitric oxide synthase, inducible(Mus musculus (mouse))
Northwestern University

US Patent
LigandPNGBDBM152721(N-(3-{2-[3-(thiophene-2-imidamido)phenoxy]ethoxy}p...)
Affinity DataKi:  6.68E+4nMAssay Description:The compounds were evaluated for in vitro inhibition against three NOS isozymes: rat nNOS, bovine eNOS and marine iNOS using known literature methods...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails US Patent
TargetNitric oxide synthase oxygenase(Bacillus subtilis (Firmicutes))
University of California Irvine

LigandPNGBDBM152721(N-(3-{2-[3-(thiophene-2-imidamido)phenoxy]ethoxy}p...)
Affinity DataKd:  1.27E+5nMAssay Description:In short, the difference between the imidazole-bound low-spin peak at 430 nm and the inhibitorbound high-spin peak at 395 nm was measured as a functi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB