BDBM153714 N-benzyl-7-(4-methylphenyl)-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine (8f)

SMILES Cc1ccc(cc1)-n1cc(-c2ccccc2)c2c(NCc3ccccc3)ncnc12

InChI Key InChIKey=KKLHTNGQSMODCC-UHFFFAOYSA-N

Data  1 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 153714   

TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Homo sapiens (Human))
Technische Universit??????T Dortmund

LigandPNGBDBM153714(N-benzyl-7-(4-methylphenyl)-5-phenyl-7H-pyrrolo[2,...)
Affinity DataKd:  6.00E+3nMpH: 7.4Assay Description:Labeled Akt1 was diluted to 200 nM in the measurement buffer consisting of 50 mMHEPES pH 7.4, 200 mM NaCl, and 0.01% Triton-X 100. Dilution series of...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Homo sapiens (Human))
Technische Universit??????T Dortmund

LigandPNGBDBM153714(N-benzyl-7-(4-methylphenyl)-5-phenyl-7H-pyrrolo[2,...)
Affinity DataIC50: >2.00E+5nMAssay Description:IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed