BDBM156129 US9018214, 180
SMILES C[C@@H]1CN(CC(=O)N2CC(C)(C)c3ncc(Cc4ccccc4)cc23)[C@@H](CN2CCCC2=O)CN1
InChI Key InChIKey=ALAFRPAHGDJVFE-NFBKMPQASA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 156129
Affinity DataIC50: 44nMpH: 7.5 T: 2°CAssay Description:Modified SMAC peptides and compounds were tested for their ability to displace the fluorescent tracer from either XIAP, clAP-1 or clAP-2. BIR3 domain...More data for this Ligand-Target Pair
TargetBaculoviral IAP repeat-containing protein 2(Homo sapiens (Human))
Astex Pharmaceuticals
Curated by ChEMBL
Astex Pharmaceuticals
Curated by ChEMBL
Affinity DataEC50: 7.5nMAssay Description:Induction of cIAP1 degradation in human MDA-MB-231 cells after 2 hrsMore data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of SMAC-derived peptide abuRPFK (5 and 6FAM)-amide interaction with XIAP BIR3 domain (unknown origin) by fluorescence polarization assayMore data for this Ligand-Target Pair
Affinity DataEC50: 120nMAssay Description:Inhibition of full length FLAG-tagged XIAP (unknown origin) interaction with full length untagged caspase-9 expressed in HEK293 cells after 2 hrs by ...More data for this Ligand-Target Pair