BDBM156414 US9023354, AD4-1505

SMILES COc1ccc(cc1O)C(Nc1cc(C)ccn1)c1ccc2cccnc2c1O

InChI Key InChIKey=FCTHDIWMHUZDNV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 156414   

TargetProtein disulfide-isomerase(Homo sapiens (Human))
University Of Michigan

Curated by ChEMBL
LigandPNGBDBM156414(US9023354, AD4-1505)
Affinity DataIC50:  150nMAssay Description:Inhibition of recombinant human wild-type N-terminal His-tagged PDIA1 expressed in Escherichia coli strain BL21(DE3) using bovine insulin as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
TBA

US Patent
LigandPNGBDBM156414(US9023354, AD4-1505)
Affinity DataIC50:  4.20E+3nMT: 2°CAssay Description:The following example describes an assay that measured the ability of compounds to inhibit the binding of p53 to MDM2 using the AlphaScreen assay tec...More data for this Ligand-Target Pair
In DepthDetails US Patent