BDBM159843 BDBM159925::US9040528, 2::US9040528, 2(b)

SMILES C[C@@H]1CN2[C@H]([C@H](C)O1)C1(Cc3cc4c(C)noc4c(F)c23)C(=O)NC(=O)NC1=O

InChI Key InChIKey=FWKBFPFKHVTISW-FCEXRKLGSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 159843   

TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Astrazeneca

US Patent
LigandPNGBDBM159843(BDBM159925 | US9040528, 2 | US9040528, 2(b))
Affinity DataIC50:  400nMpH: 7.5Assay Description:In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/ml of topologic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Astrazeneca

US Patent
LigandPNGBDBM159843(BDBM159925 | US9040528, 2 | US9040528, 2(b))
Affinity DataIC50:  300nMpH: 7.5Assay Description:In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/ml of topologic...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Astrazeneca

US Patent
LigandPNGBDBM159843(BDBM159925 | US9040528, 2 | US9040528, 2(b))
Affinity DataIC50:  0.290nMAssay Description:Inhibition of Escherichia coli DNA gyrase using fluorescence-tagged DNA by fluorescenct polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA topoisomerase 2-alpha(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM159843(BDBM159925 | US9040528, 2 | US9040528, 2(b))
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human topoisomerase 2alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA gyrase subunit A/B(Escherichia coli (strain K12))
Astrazeneca

US Patent
LigandPNGBDBM159843(BDBM159925 | US9040528, 2 | US9040528, 2(b))
Affinity DataIC50:  300nMpH: 7.5Assay Description:In a black, 384-well polystyrene assay plate, 30 microliters/well of 5 nM Escherichia coli DNA gyrase A/B tetramer and 130 micrograms/ml of topologic...More data for this Ligand-Target Pair
In DepthDetails US Patent