BDBM160666 US9045498, 8

SMILES NC1=N[C@]2(CO[C@@H](CF)C[C@H]2CS1)c1cc(CNCC(F)(F)F)c(F)cc1F

InChI Key InChIKey=KXRWMDHPUURSND-USBNGQNGSA-N

Data  9 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 160666   

TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM160666(US9045498, 8)
Affinity DataIC50:  6nMAssay Description:Inhibition of BACE1 in human H4 cells transfected with APP695 assessed as reduction in APP level incubated for 18 hrs by ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM160666(US9045498, 8)
Affinity DataIC50:  77nMAssay Description:Inhibition of BACE1 (unknown origin) expressed in CHO-K1 cells using Biotin-GLTNIKTEEISEISYAEVEFR-C[Oregon Green]KK-OH as substrate incubated for 3 h...More data for this Ligand-Target Pair