BDBM161389 US10124003, Ref. Ex. Compound 3::US10835536, Ex. Comp 2::US10894048, Ex Comp 2::US9108973, 2
SMILES COc1cc(OC)cc(c1)C#Cc1nn([C@H]2CCN(C2)C(=O)C=C)c2ncnc(N)c12
InChI Key InChIKey=KEIPNCCJPRMIAX-HNNXBMFYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 33 hits for monomerid = 161389
Affinity DataIC50: 3.60nMAssay Description:Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataIC50: 3.70nMAssay Description:Inhibition of human FGFR4More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Purified recombinant human FGFR3 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:Purified recombinant human FGFR4 protein was purchased from Carna Biosciences, Inc. When setting conditions for the measurement of the inhibitory ef...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
Affinity DataIC50: 190nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR1 kinase activity, a biotinylated peptide (biotin-EEPLYW...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:The inhibitory effect of the compounds on FGFR3 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...More data for this Ligand-Target Pair
Affinity DataIC50: 3.40nMAssay Description:The inhibitory effect of the compounds on FGFR4 kinase activity was measured according to the method of Test Example 3. Purified recombinant human FG...More data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human FGFR1 (459 to 765 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:Inhibition of human FGFR2 (458 to 768 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.530nMAssay Description:Inhibition of human FGFR3 (450 to 758 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human FGFR4 (445 to 753 residues) expressed in Escherichia coli BL21 (DE3) by HTRF assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Peking Union Medical College And Chinese Academy Of Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of BTK (unknown origin) measured by ADP-Glo assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human recombinant FGFR1 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of human recombinant FGFR2 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human recombinant FGFR3 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30nMAssay Description:Inhibition of human recombinant FGFR4 expressed in Escherichia coli BL21 DE3 assessed as inhibition by western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: <4nMAssay Description:Inhibition of recombinant wild type FGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) incubated for 120 mins by mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human recombinant cytoplasmic domain FGFR2 (8 to 134 residues) incubated for 120 mins by mobility shift assayMore data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human EGFR del19/T790M using biotinEEPLYWSFPAKKK-NH2 as substrate incubated for 120 mins by TR-FRET assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.36E+3nMAssay Description:Inhibition of N-terminal GST tagged recombinant human VEGFR2 (aa805 to 1356 residues) expressed in baculovirus expression system using Poly- (Glu4:Ty...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FGFR1More data for this Ligand-Target Pair
Affinity DataIC50: 1.60nMAssay Description:Inhibition of human FGFR3More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMpH: 7.5 T: 2°CAssay Description:When setting conditions for the measurement of the inhibitory effect of the compounds on FGFR2 kinase activity, FL-Peptide 22 (Caliper Life Sciences,...More data for this Ligand-Target Pair