BDBM16175 CHEMBL108468::UKI-1::ethyl 4-(3-carbamimidoyl-N-{[2,4,6-tris(1-methylethyl)phenyl]sulfonyl}phenylalanyl)piperazine-1-carboxylate::ethyl 4-[3-(3-carbamimidoylphenyl)-2-{[2,4,6-tris(propan-2-yl)benzene]sulfonamido}propanoyl]piperazine-1-carboxylate

SMILES CCOC(=O)N1CCN(CC1)C(=O)C(Cc1cccc(c1)C(N)=N)NS(=O)(=O)c1c(cc(cc1C(C)C)C(C)C)C(C)C

InChI Key InChIKey=ISJSHQTWOHGCMM-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 16175   

TargetSerine protease 1(Bos taurus (bovine))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16175(CHEMBL108468 | UKI-1 | ethyl 4-(3-carbamimidoyl-N-...)
Affinity DataKi:  37nM ΔG°:  -10.1kcal/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAnionic trypsin(Bos taurus)
UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM16175(CHEMBL108468 | UKI-1 | ethyl 4-(3-carbamimidoyl-N-...)
Affinity DataKi:  120nMAssay Description:Tested for inhibition of trypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16175(CHEMBL108468 | UKI-1 | ethyl 4-(3-carbamimidoyl-N-...)
Affinity DataKi:  410nM ΔG°:  -8.71kcal/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16175(CHEMBL108468 | UKI-1 | ethyl 4-(3-carbamimidoyl-N-...)
Affinity DataKi:  960nMAssay Description:Tested for inhibition of plasminogen activator urokinase (microPa)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
UniversitäT Jena

Curated by ChEMBL
LigandPNGBDBM16175(CHEMBL108468 | UKI-1 | ethyl 4-(3-carbamimidoyl-N-...)
Affinity DataKi:  1.20E+3nMAssay Description:Tested for inhibition of plasminMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Max-Planck-Institut Fuer Biochemie

LigandPNGBDBM16175(CHEMBL108468 | UKI-1 | ethyl 4-(3-carbamimidoyl-N-...)
Affinity DataKi:  4.90E+3nM ΔG°:  -7.24kcal/molepH: 8.0 T: 2°CAssay Description:The measurements were carried out on a microplate reader. Two concentrations of the substrate and five concentrations of the inhibitor were used in t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed