BDBM16285 2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl}methyl)benzonitrile::2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl}methyl)benzonitrile::Alogliptin::SYR-322

SMILES Cn1c(=O)cc(N2CCC[C@@H](N)C2)n(Cc2ccccc2C#N)c1=O

InChI Key InChIKey=ZSBOMTDTBDDKMP-OAHLLOKOSA-N

Data  52 IC50  2 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 16285   

TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged DPP9 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged DPP8 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 secs interval f...More data for this Ligand-Target Pair
TargetDipeptidyl peptidase 9(Homo sapiens (Human))
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged DPP9 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 8(Homo sapiens (Human))
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant full-length human N-terminal GST-tagged DPP8 expressed in Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 se...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Guangxi Medical University

Curated by ChEMBL
LigandPNGBDBM16285(2-({6-[(3R)-3-aminopiperidin-1-yl]-3-methyl-2,4-di...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of recombinant human DPP4 expressed in baculovirus infected Sf9 insect cells using Gly-Pro-AMC as substrate measured at 60 secs interval f...More data for this Ligand-Target Pair