BDBM16306 2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximidamide::2-pyridin-2-yl-1H-benzimidazole-6-carboximidamide::APD-4::CHEMBL381148

SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1ccccn1

InChI Key InChIKey=RVIFTTGMSLOWED-UHFFFAOYSA-N

Data  11 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 16306   

TargetCoagulation factor X(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM16306(2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximida...)
Affinity DataKi:  27nMAssay Description:Binding affinity to FXa in presence of Zn2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM16306(2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximida...)
Affinity DataKi:  720nMAssay Description:Binding affinity to thrombin in presence of Zn2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM16306(2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximida...)
Affinity DataKi:  721nM ΔG°:  -8.29kcal/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM16306(2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximida...)
Affinity DataKi:  1.45E+3nMAssay Description:Binding affinity to FVIIa in presence of Zn2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Arris

LigandPNGBDBM16306(2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximida...)
Affinity DataKi:  1.60E+3nM ΔG°:  -7.82kcal/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Arris

LigandPNGBDBM16306(2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximida...)
Affinity DataKi:  1.93E+4nMAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Arris

LigandPNGBDBM16306(2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximida...)
Affinity DataKi:  2.09E+4nM ΔG°:  -6.32kcal/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM16306(2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximida...)
Affinity DataKi:  4.56E+4nMAssay Description:Binding affinity to FXa in absence of Zn2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM16306(2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximida...)
Affinity DataKi:  6.00E+4nMAssay Description:Binding affinity to thrombin in absence of Zn2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Celera

Curated by ChEMBL
LigandPNGBDBM16306(2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximida...)
Affinity DataKi:  8.15E+4nMAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Arris

LigandPNGBDBM16306(2-(pyridin-2-yl)-1H-1,3-benzodiazole-6-carboximida...)
Affinity DataKi:  1.01E+5nMAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed