BDBM16308 2-(isoquinolin-1-yl)-1H-1,3-benzodiazole-6-carboximidamide::2-isoquinolin-1-yl-1H-benzimidazole-6-carboximidamide::APD-6

SMILES NC(=N)c1ccc2nc([nH]c2c1)-c1nccc2ccccc12

InChI Key InChIKey=ICDCECQARHLULZ-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 16308   

TargetProthrombin(Homo sapiens (Human))
Arris

LigandPNGBDBM16308(2-(isoquinolin-1-yl)-1H-1,3-benzodiazole-6-carboxi...)
Affinity DataKi:  41nM ΔG°:  -9.97kcal/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Arris

LigandPNGBDBM16308(2-(isoquinolin-1-yl)-1H-1,3-benzodiazole-6-carboxi...)
Affinity DataKi:  8.80E+3nMAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Arris

LigandPNGBDBM16308(2-(isoquinolin-1-yl)-1H-1,3-benzodiazole-6-carboxi...)
Affinity DataKi:  2.25E+4nM ΔG°:  -6.27kcal/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Arris

LigandPNGBDBM16308(2-(isoquinolin-1-yl)-1H-1,3-benzodiazole-6-carboxi...)
Affinity DataKi:  3.10E+4nMAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Homo sapiens (Human))
Arris

LigandPNGBDBM16308(2-(isoquinolin-1-yl)-1H-1,3-benzodiazole-6-carboxi...)
Affinity DataKi:  3.12E+4nMAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTryptase beta-2(Homo sapiens (Human))
Arris

LigandPNGBDBM16308(2-(isoquinolin-1-yl)-1H-1,3-benzodiazole-6-carboxi...)
Affinity DataKi:  5.45E+4nM ΔG°:  -5.75kcal/molepH: 8.2 T: 2°CAssay Description:Enzymes were incubated with inhibitors at eight inhibitor concentrations bracketing the Ki, prepared by serial dilution along with control lacking th...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed