BDBM164266 US9669029, 16 5,7-Dimethyl-2-{2-[4-thiophen-2-yl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-ethyl}-imidazo[1,2-a]pyrimidine

SMILES Cc1cc(C)n2cc(CCc3nc(cn3COCC[Si](C)(C)C)-c3-[s]ccc3)nc2n1

InChI Key InChIKey=VVTUCTFPGOVURX-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 164266   

TargetcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A [440-779](Homo sapiens (Human))
H. Lundbeck

US Patent
LigandPNGBDBM164266(US9669029, 16 5,7-Dimethyl-2-{2-[4-thiophen-2-yl-1...)
Affinity DataIC50:  9.60nMT: 2°CAssay Description:The assay is performed in 60 uL samples containing a fixed amount of the relevant PDE enzyme (sufficient to convert 20-25% of the cyclic nucleotide s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent