BDBM16732 1-{4-(Phenyl)-2-[(naphthalene-1-carbonyl)-amino]-phenyl}-4-[1-(5-phthalimido)-pentyl]-piperazine::N-(2-{4-[5-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)pentyl]piperazin-1-yl}-5-phenylphenyl)naphthalene-1-carboxamide::Naphthyl Compound, 5c

SMILES O=C(Nc1cc(ccc1N1CCN(CCCCCN2C(=O)c3ccccc3C2=O)CC1)-c1ccccc1)c1cccc2ccccc12

InChI Key InChIKey=HQMXPAYDWPIZSY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16732   

TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16732(1-{4-(Phenyl)-2-[(naphthalene-1-carbonyl)-amino]-p...)
Affinity DataIC50:  100nMAssay Description:Inhibition of BACE1 after 2 hrs by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Applied Science University

Curated by ChEMBL
LigandPNGBDBM16732(1-{4-(Phenyl)-2-[(naphthalene-1-carbonyl)-amino]-p...)
Affinity DataIC50:  100nMpH: 7.5 T: 2°CAssay Description:These experiments have been preformed using BACE-1 FRET assay kit (PanVera Corporation, Madison, WI), using a multiwell spectrofluorometer instrument...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed