BDBM16818 (2S)-2-[(2,6-dichlorophenyl)formamido]-3-(4-{2-methyl-5-[2-(morpholin-4-yl)ethoxy]-3-oxo-2,3-dihydropyridazin-4-yl}phenyl)propanoic acid::(S)-2-(2,6-Dichloro-benzoylamino)-3-{4-[2-methyl-5-(2-morpholin-4-yl-ethoxy)-3-oxo-2,3-dihydro-pyridazin-4-yl]-phenyl}-propionic Acid::pyridazinone-based antagonist, 20

SMILES Cn1ncc(OCCN2CCOCC2)c(-c2ccc(C[C@H](NC(=O)c3c(Cl)cccc3Cl)C(O)=O)cc2)c1=O

InChI Key InChIKey=FUCBSFYEWUNIOP-NRFANRHFSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 16818   

TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM16818((2S)-2-[(2,6-dichlorophenyl)formamido]-3-(4-{2-met...)
Affinity DataIC50:  3nMT: 2°CAssay Description:M2 anti-FLAG antibody coated 96-well plates were coated with recombinant FLAG-hMAdCAM-1 contained in Dulbecco PBS. The compounds to be tested were ad...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4/beta-1 [T112H](Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM16818((2S)-2-[(2,6-dichlorophenyl)formamido]-3-(4-{2-met...)
Affinity DataIC50:  66nMpH: 7.4 T: 2°CAssay Description: Immulon 96-well plates were coated with recombinant hVCAM-1 overnight at 4 C. Plates were washed and blocked for 1 h at room temperature in PBS-BSA....More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed