BDBM17060 1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(piperidin-4-yl)-1,2,3,4-tetrahydroquinazolin-2-one::CHEMBL319556::Dihydro-quinazolinone analog, 9

SMILES Fc1ccc(c(F)c1)-c1cc(cc2N(C(=O)NCc12)c1c(Cl)cccc1Cl)C1CCNCC1

InChI Key InChIKey=NEQVXWUMTYNMHH-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 17060   

TargetMitogen-activated protein kinase 14(Mus musculus (mouse))
Merck Research Laboratories

LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50:  0.200nMpH: 7.0 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with p38 enzyme, and substrates in the presence ATP/[gamma-33P] ATP. After the rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of c-Jun N-terminal kinase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Protein tyrosine kinase LynMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of p56 Lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Src protein tryrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Janus kinase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p38alpha MAPK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Janus kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Extracellular signal-regulated kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Fyn protein kinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Tyrosine kinase 2 kinase, tyk-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against mitogen-activated protein kinase p38 alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM17060(1-(2,6-dichlorophenyl)-5-(2,4-difluorophenyl)-7-(p...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Janus kinase 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed