BDBM17298 4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclopropyl]-1H-1,3-benzodiazol-2-yl}methyl)amino]benzene-1-carboximidamide::BIBM1015

SMILES Cn1c(CNc2ccc(cc2)C(N)=N)nc2cc(ccc12)C1(CC1)C(=O)N1CCCC1

InChI Key InChIKey=HGNSKHRWYAJRBQ-UHFFFAOYSA-N

Data  8 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 17298   

TargetCoagulation factor X(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  15nM ΔG°:  -11.1kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  20nM ΔG°:  -10.9kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine protease 1(Bos taurus (bovine))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  102nM ΔG°:  -9.91kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetUrokinase-type plasminogen activator(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  6.50E+3nM ΔG°:  -7.36kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor XI(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  8.20E+3nM ΔG°:  -7.21kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlasminogen(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi:  1.30E+4nM ΔG°:  -6.93kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTissue-type plasminogen activator(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi: >3.00E+4nM ΔG°: >-6.41kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataKi: >4.00E+4nM ΔG°: >-6.24kcal/molepH: 8.0 T: 2°CAssay Description:For determination of the inhibition constants (Ki), enzyme inhibition was studied at three different substrate concentrations and seven different con...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Boehringer Ingelheim Pharma

LigandPNGBDBM17298(4-[({1-methyl-5-[1-(pyrrolidin-1-ylcarbonyl)cyclop...)
Affinity DataIC50:  15nMAssay Description:Inhibition of factor-10a (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed