BDBM173979 US9688661, 3-[2-Ethyl-5-(trifluoromethyl)phenyl]-N-methyl-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrrole-2-carboxamide (compd 131)

SMILES CCc1ccc(cc1-c1cc(-c2ncnc3[nH]ccc23)n(C)c1C(N)=O)C(F)(F)F

InChI Key InChIKey=BXMANWMUJJUHIP-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 173979   

TargetTyrosine-protein kinase JAK1 [861-1152](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM173979(US9688661, 3-[2-Ethyl-5-(trifluoromethyl)phenyl]-N...)
Affinity DataIC50:  25nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM173979(US9688661, 3-[2-Ethyl-5-(trifluoromethyl)phenyl]-N...)
Affinity DataIC50:  87nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM173979(US9688661, 3-[2-Ethyl-5-(trifluoromethyl)phenyl]-N...)
Affinity DataIC50:  9nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent