BDBM174013 4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piperazine-1-carboxylic acid (4-chloro-pyridin-3-yl)-amide::US9688664, 1

SMILES FC1(F)Oc2ccc(CN3CCN(CC3)C(=O)Nc3cnccc3Cl)cc2O1

InChI Key InChIKey=YWGYNGCRVZLMCS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 174013   

TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174013(4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...)
Affinity DataIC50:  75nMpH: 9.0Assay Description:T84 frozen cell pellets or transfected SK-N-MC cells (contents of 1×15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174013(4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...)
Affinity DataIC50:  1.10E+4nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2D6(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174013(4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...)
Affinity DataIC50:  2.40E+4nMpH: 7.4Assay Description:The assay was set up and executed using a Biomek FXp robotic liquid handling workstation (Beckman Coulter Corp., Fullerton, Calif.), integrated with ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
Janssen Pharmaceutica

US Patent
LigandPNGBDBM174013(4-(2,2-difluoro-benzo[1,3]dioxol-5-ylmethyl)-piper...)
Affinity DataIC50:  320nMpH: 9.0Assay Description:Transfected SK-N-MC cells (contents of 1×15 cm culture dishes) were homogenized in 50 mL of FAAH assay buffer (125 mM Tris, 1 mM EDTA, 0.2% Glycerol,...More data for this Ligand-Target Pair
In DepthDetails US Patent