BDBM174027 US9688661, 4-(6-Aminopyrimidin-4-yl)-1-[2-ethyl-5-(trifluoromethyl)phenyl]-1H-pyrrole-2-carboxamide (compd 256)

SMILES CCc1ccc(cc1-c1cn(cc1C(N)=O)-c1cc(N)ncn1)C(F)(F)F

InChI Key InChIKey=SJNAYKPQKOYZEU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 174027   

TargetTyrosine-protein kinase JAK1 [861-1152](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174027(US9688661, 4-(6-Aminopyrimidin-4-yl)-1-[2-ethyl-5-...)
Affinity DataIC50:  53nMAssay Description:Assays were performed with the JAK1 kinase domain (residues 861-1152 of the 1154 amino acid long full-length sequence, accession number P23458 of Uni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNon-receptor tyrosine-protein kinase TYK2 [833-1187](Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174027(US9688661, 4-(6-Aminopyrimidin-4-yl)-1-[2-ethyl-5-...)
Affinity DataIC50:  31nMAssay Description:Assays were performed with the TYK2 kinase domain (residues 833-1187 of the 1187 amino acid long full-length sequence, accession number P29597 of Uni...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Nerviano Medical Sciences

US Patent
LigandPNGBDBM174027(US9688661, 4-(6-Aminopyrimidin-4-yl)-1-[2-ethyl-5-...)
Affinity DataIC50:  6nMAssay Description:Assays were performed with the commercially available JAK2 kinase domain (Invitrogen, Eugene, Oreg.) that showed a linear kinetic without prephosphor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent