BDBM17718 2,3-Diarylfuro[2,3-b]pyridine-4-amine, 14::3-phenyl-N-[2-(piperazin-1-yl)ethyl]-2-{4-[2-(pyrrolidin-1-yl)ethoxy]phenyl}furo[2,3-b]pyridin-4-amine

SMILES C(CN1CCNCC1)Nc1ccnc2oc(c(-c3ccccc3)c12)-c1ccc(OCCN2CCCC2)cc1

InChI Key InChIKey=JPVQIIJQJZQGID-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 17718   

TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Amgen

LigandPNGBDBM17718(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 14 | 3-phen...)
Affinity DataIC50:  210nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Amgen

LigandPNGBDBM17718(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 14 | 3-phen...)
Affinity DataIC50:  110nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivated CDC42 kinase 1(Homo sapiens (Human))
Amgen

LigandPNGBDBM17718(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 14 | 3-phen...)
Affinity DataIC50:  170nMAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Amgen

LigandPNGBDBM17718(2,3-Diarylfuro[2,3-b]pyridine-4-amine, 14 | 3-phen...)
Affinity DataIC50:  54nMpH: 7.5 T: 2°CAssay Description:The assay involves the phosphorylation of a biotinylated substrate and the detection of this phosphorylation after the addition of a streptavidin-all...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed