BDBM17843 (Hydroxyethyl)hydrazine Isostere-Based Compound, 32::methyl N-[(1S)-1-{N'-[(2S,3S)-2-hydroxy-3-{[(5S)-2-oxo-3-phenyl-1,3-oxazolidin-5-yl]formamido}-4-phenylbutyl]-N'-(2-methylpropyl)hydrazinecarbonyl}-2,2-dimethylpropyl]carbamate

SMILES COC(=O)N[C@H](C(=O)NN(CC(C)C)C[C@H](O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CN(C(=O)O1)c1ccccc1)C(C)(C)C

InChI Key InChIKey=HURZZMNNKMZLQC-YIPNQBBMSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 17843   

TargetDimer of Gag-Pol polyprotein [491-589,Q496K](Human immunodeficiency virus type 1)
University of Massachusetts Medical School

LigandPNGBDBM17843((Hydroxyethyl)hydrazine Isostere-Based Compound, 3...)
Affinity DataKi:  7nM ΔG°:  -11.3kcal/molepH: 4.7 T: 2°CAssay Description:HIV-1 protease inhibitor activities were determined by the fluorescence resonance energy transfer (FRET) method. The energy transfer donor (EDANS) an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [491-589,Q498K,D521N,V555I,N579D](Human immunodeficiency virus type 1)
University of Massachusetts Medical School

LigandPNGBDBM17843((Hydroxyethyl)hydrazine Isostere-Based Compound, 3...)
Affinity DataKi:  39.2nMAssay Description:HIV-1 protease inhibitor activities were determined by the fluorescence resonance energy transfer (FRET) method. The energy transfer donor (EDANS) an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [491-589,Q498K,L501I,G539V,I545V,V555I,V573A](Human immunodeficiency virus type 1)
University of Massachusetts Medical School

LigandPNGBDBM17843((Hydroxyethyl)hydrazine Isostere-Based Compound, 3...)
Affinity DataKi:  231nMAssay Description:HIV-1 protease inhibitor activities were determined by the fluorescence resonance energy transfer (FRET) method. The energy transfer donor (EDANS) an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDimer of Gag-Pol polyprotein [491-589,Q498K,L501I,V555I,A562V,G564S,I575V,L581M](Human immunodeficiency virus type 1)
University of Massachusetts Medical School

LigandPNGBDBM17843((Hydroxyethyl)hydrazine Isostere-Based Compound, 3...)
Affinity DataKi:  549nMAssay Description:HIV-1 protease inhibitor activities were determined by the fluorescence resonance energy transfer (FRET) method. The energy transfer donor (EDANS) an...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed