BDBM179801 3-((2,6-dichloro-3-fluorophenyl)thio)-5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrazolo[3,4-b]pyridine (9)
SMILES Fc1ccc(Cl)c(Sc2n[nH]c3ncc(cc23)-c2cnn(c2)C2CCNCC2)c1Cl
InChI Key InChIKey=FCLVBOUURHAHBG-UHFFFAOYSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 179801
TargetIsoform 2 of Hepatocyte growth factor receptor (2)(Homo sapiens (Human))
Tianjin University of Science and Technology
Tianjin University of Science and Technology
Affinity DataIC50: 22.8nMpH: 7.0 T: 2°CAssay Description:The c-Met kinase activity of five target compounds and three positive compounds were evaluated using standard Z-LYTE Assays (fluorescence resonance e...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tianjin University of Science and Technology
Tianjin University of Science and Technology
Affinity DataIC50: 135nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor [C1156Y](Homo sapiens (Human))
Tianjin University of Science and Technology
Tianjin University of Science and Technology
Affinity DataIC50: 651nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tianjin University of Science and Technology
Tianjin University of Science and Technology
Affinity DataIC50: 578nMAssay Description:Inhibition of ALK L1196M mutant (unknown origin) using biotin-TK peptide as substrate in presence of ATP incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant c-Met (unknown origin) using poly Tyrosine peptide as substrate in presence of ATP incubated for 90 mins by Z-LYTE assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tianjin University of Science and Technology
Tianjin University of Science and Technology
Affinity DataIC50: 135nMAssay Description:Inhibition of wild type ALK (unknown origin) using biotin-TK peptide as substrate in presence of ATP incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Tianjin University of Science and Technology
Tianjin University of Science and Technology
Affinity DataIC50: 651nMAssay Description:Inhibition of ALK C1156Y mutant (unknown origin) using biotin-TK peptide as substrate in presence of ATP incubated for 90 mins by HTRF assayMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor [L1196M](Homo sapiens (Human))
Tianjin University of Science and Technology
Tianjin University of Science and Technology
Affinity DataIC50: 578nMpH: 7.5 T: 2°CAssay Description:The ALK kinase activity of five target compounds and three positive compounds were evaluated using standard homogeneous time-resolved fluorescence (H...More data for this Ligand-Target Pair